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This initiates the extrinsic pathway and further amplifies mitochondrial damage through BH3 interacting domain death agonist (BID) cleavage, linking both pathways at the mitochondrial level (Stergiou and Hengartner 2004)

A randomized, double-blind, placebo-controlled, stratified trial of riluzole 100 mg daily, given as 50 mg twice daily, demonstrated a statistically significant survival benefit at 12 and 21 months, with median survival increasing by 83 days [113], with more robust survival effect seen in patients with bulbar onset disease

Asadbegi M, Yaghmaei P, Salehi I et al (2016) Neuroprotective effects of metformin against A-mediated inhibition of long-term potentiation in rats fed a high-fat diet

Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes

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Increased C-reactive protein concentrations were associated with suicidal behavior in patients with depressive disorders: a meta-analysis