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For each assay, established enzyme specific inhibitors were included as positive controls for enzyme function and assay reproducibility

Recent studies have shown a correlation between ferroptosis and the pathological mechanisms of neurodegenerative diseases, as well as diseases involving tissue or organ damage

Bakhoum SF, Ngo B, Laughney AM et al (2018) Chromosomal instability drives metastasis through a cytosolic DNA response

They have a positive test for the Nikolsky sign, which manifests blisters and skin erosion upon a gentle rubbing on the lesion and leaves a glistening surface beneath [12]

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J Food Agric Environ 11:165171 Marsik P, Kokoska L, Landa P, Nepovim A, Soudek P, Vanek T (2005) In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and 2-catalyzed prostaglandin E2 biosyntheses