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This compromised barrier facilitates the translocation of harmful microorganisms, such as Escherichia coli , from the gut lumen into systemic circulation, thereby exacerbating systemic inflammation ( Pseudoflavonifractor , Clostridium , Alistipes , Faecalibacterium , Oscillibacter ) and secondary bile acid producers ( Eubacterium rectale , Clostridium scindens , Bacteroides fragilis ) are observed in prediabetic and type 2 diabetic individuals