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Additionally, histone lactylation upregulates Prelamin A to induce PASMC senescence, which subsequently triggers a SASP and the release of IL-6 to stimulate neighboring cell proliferation via paracrine signaling

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Atherosclerosis 278 , 197209 (2018)

As the literature expands on the links between gut dysbiosis and the broader symptomatology of ME/CFS, it becomes increasingly necessary to integrate this knowledge into clinical practice, reinforcing perspectives that prioritize holistic treatment methodologies in an often fragmented care landscape

doi: 10.1186/s43088-020-00065-9 22 FanD.WangX.TangX.YeX.RenS.WangD.et al