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DSM-5 defines ASD as a persistent condition affecting two core areas: social communication and restricted or repetitive behaviors

It involves a diverse array of ROS species generated from multiple sources with distinct reactivities and temporal patterns throughout ischemia and reperfusion

Importantly, eradication therapy has been shown to partially reverse these metabolic abnormalities, accompanied by downregulation of key lipid regulatory genes such as FABP1 and MTP, and a consistent increase in HDL-C and apolipoprotein A levels (Tsai et al., 2006

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Building on prior research, Sotolongo and Ward [106] provided evidence that spermatozoa reach the epididymis and contain a less compact DNA strand, making them inert and unable to perform their functions effectively

CONCLUSION This review outlines the key mechanisms of metabolic reprogramming in HCC and their impact on the TME, highlighting therapeutic opportunities based on metabolic targeting