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204 The accumulation of the hyperphosphorylated tau protein, a type of microtubule-associated protein (MAP), induces the formation of neurofibrillary tangles, and the aggregation of the amyloid-beta 1-42 (A42) fragment produced from APP results in the formation of senile plaques by disturbing the activity of PS1 and PS2

PMID 19713987

When compared with systemic treatments, this approach would have clear dose-sparing and precision targeting potential, since the lymphatic drainage will carry peri- or intratumorally injected therapeutic antibodies by default to the same LNs, which drain the metastatic cells escaping from the primary tumor

It is important for all regular caregivers to share the responsibility of giving the injection

400 These findings suggest that minihepcidins could be used alone to prevent iron overload disease or as an adjunct therapy with iron chelating agents

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