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Key Takeaways Vitamin B12 is crucial for energy, brain health, and red blood cell production

NNMT-mediated SAM depletion can alter cell MP, contributing to the change in global epigenetic histone profiles in cancer (93)

65 66 Case example

Vitamin B12 injections are typically administered intramuscularly, which means they are injected directly into the muscle tissue

The lack of statistical significance in sensitivity analyses stratified by other ARV use may be attributed in part to the small sample sizes, especially in the groups who used TDF and/or EFV before switch only ( n = 8), who used TDF and/or EFV before and TDF after switch ( n = 27), who did not use any INSTI or TAF ( n = 18), and who used TAF without any INSTIs ( n = 28)