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IGF-1 peptides (LR3, Des) increase systemic or local IGF-1 levels potentially supporting musculoskeletal repair alongside muscle effects

Research endpoints include epithelial-barrier integrity, cytoprotective signaling, inflammatory-response markers, peptide biodistribution, and comparisons with parenteral delivery models

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Patients following vegetarian or vegan diets may need additional B12 supplementation, as this vitamin is primarily found in animal products

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Differences in peptide purity, identity, or manufacturing consistency can affect experimental reproducibility