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In inflamed or diabetic wounds, keratinocytes, fibroblasts, and macrophages overexpress CD44, while the excessive accumulation of ROS generates a redox-imbalanced milieu analogous to tumor oxidative stress

This versatility, combined with its well-documented safety profile in pre-clinical models and its stable behaviour in laboratory settings, has made it one of the most widely sourced research peptides globally

It was reported that p53 could promote ferroptosis by repressing the expression of SLC7A11 in both transcriptional and non-transcriptional manners, which led to the decreased uptake of Cys2 and impaired GSH biogenesis[40, 41]

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