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Simultaneously, MPs/NPs impair lysosomal degradation pathways, exacerbating intraneuronal -synuclein accumulation and promoting the formation of Lewy bodies

9,10 Sustained intakes above this can cause selenosis, with symptoms including hair loss, brittle nails, a garlic odour on the breath, digestive upset, and, at high levels, nerve problems

Hirode G, Choi HSJ, Chen CH, et al

doi: 10.1016/J.MTCHEM.2018.05.002 84 Jacobo-DelgadoY

W., Fu, C

However, these regimens have shortcomings like medication associated issues (susceptibility to infections, liver problems, bone density loss, and allergic reactions), limited efficacy (frequent flare-ups), biologic therapy risks (infusion reactions, may reduce the effectiveness of antibodies), surgery considerations (may cause potential complications), cost and accessibility (biologics and JAK inhibitors), psychological impact etc