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Consequently, PHGDH suppresses c-JUN poly(ADP-ribosyl)ation by both limiting NAD availability and directly binding to c-JUN, thereby blocking c-JUNdriven proliferation [115]

Inflammation is another relevant component in AD, with microglia being reported altered as early as in the first descriptions of the disease by Alois Alzheimers [84]

In vivo , C75 treatment restored endothelial function and reversed erectile dysfunction, accompanied by decreased oxidative stress and pyroptosis in the penile corpus cavernosum