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For instance, among the included 248 patients with AP (124 patients in each group), Chaiqinchengqi decoction treatment reduced the duration of 28-day respiratory failure (median: 1.0 days, 95% confidence interval: 2.0 to 0.0) and improve 6-month clinical outcomes in AP patients compared with the placebo ( Dachengqi decoction , as adjunctive therapy, reduced multiple organ dysfunction syndrome incidence by 40% and pancreatic infection risk by 5% in severe AP patients ( Tongfu powder treatment alleviated gastrointestinal dysfunction in AP cohorts (Miao et al., 2018)

2 Antioxidant activity As a potent redox regulator, melatonin (MLT) exhibits dual antioxidant mechanisms: executing direct ROS/RNS neutralization while concurrently upregulating endogenous antioxidant enzymatic systems through catalytic proficiency modulation, and its main antioxidant effect is the formation of N-acetyl-5-methoxytryptophan (AMK), deformed from the metabolite of melatonin, N1-acetyl-N2-formyl-5-methoxykynurenine (AFMK) (Galano et al., 2013)

Biomed Technol

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& Neuhaus, J

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