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Within these motifs, some sequences showed alterations, such as: in GPX2 homolog of V

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Combined with the Materia Medica examination, it can be seen that the medicinal and edible properties of PL have been uninterrupted since ancient times, and throughout the world, PL is mainly distributed in Asia and some parts of Europe and America (Figure 2)

Growing evidence has shown that exposure to CIH fosters the development of stable genotypic and phenotypic traits, which can significantly enhance tumor advancement (Verduzco et al., 2015) and modulate the communication between tumor cells and stromal cells via the COX-2/PGE2 signaling pathway (Picado and Roca-Ferrer, 2020)