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For example, free heme triggers macrophage Toll like receptor 4 (TLR4) activation and TNF- production, as well as ROS-mediated NLRP3 inflammasome induction (7779) via binding by macrophage Fc and lectin-like receptors (80), and that such parasites may be more susceptible to ROS (81)

Kuo et al., 2013)

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For cell treatment by APAP precursors, HepaRG cells and primary human hepatocytes were first incubated with 50 g/ml of APAP or APAP-cys in the maintenance medium described above, during 0.5 h, 2 h, 6 h, 24 h, or 48 h, to optimize the incubation time required to detect APAP metabolites

10.3390/ijms19092549 21 BrodinH