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Effects of exercise training on excitation-contraction coupling and related mRNA expression in hearts of Goto-Kakizaki type 2 diabetic rats

They block key enzymes, disrupt antioxidant systems, and generate free radicals

Aono S, Yamada Y, Keino H, Hanada N, Nakagawa T, Sasaoka Y et al

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For instance, levomilnaciprans effects are associated with upregulation of the anti-aging protein -Klotho, which has downstream regulatory effects on oxidative stress and inflammation