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All aromatic hydrocarbons presented in Figure 5 have to be converted to their N-hydroxy compounds, which are the ultimate or proximate carcinogenic forms

Activated HIF-1 enters the cell nucleus, where it binds to the promoters of the xanthine dehydrogenase (XDH) and 5-nucleotidase II (NT5C2) genes, thereby upregulating the expression of XDH and NT5C2

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doi: 10.1002/smll.202406942 126 ZhangJGangwarSBanoNAhmadSAlqahtaniMSRazaK

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Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)--induced oxidative stress, colitis and hepatotoxicity in mice