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doi: 10.1016/j.fertnstert.2013.08.032 58 SenguptaP

They make the CaSR more sensitive to [Ca2+e], in contrast to the so-called calcilytics which decrease its sensitivity, as schematically shown in Figure 20

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Flaherty 1 , Hongmei Mo 1 , Namiki Izumi 5 , Maria Buti 6 , Dr Shalimar 7 and Young-Suk Lim 8 , (1)Gilead Sciences, Inc., (2)Chinese University of Hong Kong, Hong Kong, China, (3)Beaujon Hospital, (4)NYU Grossman School of Medicine, (5)Department of Gastroenterology and Hepatology, Japanese Red Cross Musashino Hospital, (6)Hospital Universitario Vall D'hebron and Ciberehd Del Instituto Carlos III, (7)All India Institute of Medical Sciences, New Delhi, (8)Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of (South) Background: Tenofovir alafenamide (TAF) has shown similar efficacy and improved safety profiles for treatment of patients with chronic hepatitis B (CHB) compared to tenofovir disoproxil fumarate (TDF)