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Molecular targeted therapy (MTT: n=56), the combination of locoregional therapy (LT) and MTT (n=22), catheter therapy (n=5), liver resection (n=1) and best supportive care (BSC: n=18) were performed as subsequent therapies, and OR rate assessed by mRECIST was 12.5%, 77.3%, 20.0%, 100.0% and 0.0%

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Synergistic Integration The combination breaks the stress-sleep disruption cycle by reducing daytime anxiety that interferes with sleep onset while promoting deep restorative sleep that strengthens stress resiliencecreating positive reinforcement between stress management and sleep quality for comprehensive nervous system optimization