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When the body detects these pathogens, the immune system launches a massive defensive response, releasing pro-inflammatory cytokines like IL-6 and TNF- in what is sometimes called a "cytokine storm." While this inflammatory response is necessary to destroy the virus, it comes at a steep metabolic cost

Disruption of these regulatory mechanisms elevates labile iron pools, potentiating Fenton reactions and ferroptosis

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Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model

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The optimal dosage, timing, and duration of melatonin supplementation remain the foci of ongoing research