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In addition to this, the reactive doxorubicin semiquinone radical can be recycled back to doxorubicin, generating an O 2 - superoxide that leads to reactive H 2 O 2 formation, which is neutralised into H 2 O by the conversion of reduced glutathione (GSH) into its oxidised form (GSSG)

Characterization of mammalian selenoprotein O: A redox-active mitochondrial protein

doi: 10.1053/j.gastro.2011.07.045 76 BagchiDMcGinnTRYeXBagchiMKrohnRLChatterjeeAet al

However, it is not all rosy news with this protein

Images were captured using a Leica M205 FA fluorescent microscope and a Leica DFC 365 FX camera (the same machine used in the above-mentioned RNAi screening)