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Increase to 0.5 mg weekly for the next 4 weeks

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A population-based study from New Zealand published in 2021 reported an overall incidence of 1.93/100,000 from 2008 to 2016, with a significant increase of the incidence from the first 3 years of the observation period to the last three years (1.372.39)

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(2017), Clinical, Cosmetic and Investigational Dermatology , reviewed both topical and oral glutathione studies for skin lightening, concluding that effects are generally modest and reversible upon discontinuation