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During the initial sensitization phase, cutaneous Langerhans cells capture the antigen and migrate to regional lymph nodes to generate memory T cells

The most prominent effects of this combination, FOS+GOS, include diminished baseline and stress-induced corticosterone and a decrease in splenic IL-6 and TNF- levels under chronic stress (Burokas et al., 2017)

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Table 2 summarizes the key metabolic alterations observed in neurons, astrocytes, and microglia across major neurodegenerative diseases

An association study on the risk, glucocorticoids effectiveness, and prognosis of systemic lupus erythematosus: insight from mitochondrial DNA copy number

First, in non-malignant tissues, PDK isoforms play essential physiological roles, particularly in highly energy-demanding organs such as the heart and skeletal muscle, where they regulate substrate utilization by limiting carbohydrate oxidation and promoting metabolic flexibility [190, 191]