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It is well established that iron overload and more generally ferroptosis can trigger macrophage polarization, increasing M1-like markers such as IL-6, IL-1, and TNF, while decreasing M2-like markers [25, 26]

Beyond mRNA, RNA interferences (RNAi) platforms (siRNAs, miRNA, and lncRNA-coding RNAs) enable sequence specific silencing of aberrant genes (Friedrich and Aigner, 2022