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The neurotoxicity of the polyglutamine androgen receptor may involve generation of NH 2 -terminal truncation fragments, as such peptides occur in SBMA patients, but several other mechanisms have also been suggested for the molecular basis of SBMA (84, 85)

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The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer

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The Wnt/-catenin pathway benefits ferroptosis by promoting -catenin binding to TCF/LEF transcription factors, which in turn reduces GPX4 activity and increases lipid peroxidation (Wang et al., 2022)

Speak with your healthcare provider to determine if this option is suitable for you