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Given that we have established selenoproteins such as GPx3 and SELENOP to be substantially reduced in those affected with disease using multiple applications and cohorts, perhaps a reduction in the ability to effectively manage oxidative damage is a leading factor for disease susceptibility and severity, when all other risk factors have been met, which are typically present even in those without konzo

Geier DA, Kern J, Garver CR, Adams JB, Audhya T, Geier MR: A prospective study of transsulfuration biomarkers in autistic disorders

, tumor protein p53 (TP53, also known as p53) and nuclear factor-B (NF-B), and activator protein 1 (AP-1)), kinases ( e.g

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PLoS ONE 16:e0251408

This modification, being the most prevalent form of mRNA modification in eukaryotes, has emerged as a pivotal focus in biomedical research