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doi: 10.3389/fendo.2023.1070264 161 JinHZhaoKLiJXuZLiaoSSunS

A significant increase in midazolam exposure (respectively from 3.02-fold to 26.41-fold for AUC and from 1.15-fold to 4.27-fold for C max ) in healthy volunteers concomitantly treated with ritonavir alone or ritonavir-boosted PIs has been reported, caused by strong inhibition of CYP3A4 [92,93,94,95]

Finally, through multicenter, large-sample clinical cohort studies combined with statistical methods, derive and validate clinically meaningful cutoff values to enable precise patient stratification and individualized treatment

At the species level, there was an increase in the abundance of Intestinibacter sp900540355 , Phocaeicola plebeius , Pseudoruminococcus massiliensis , Rikenella microfusus , Barnesiella intestinihominis , CAG-452 sp000434035 , Bacteroides fragilis , Turicibacter sanguinis , and Alistipes communis and decrease in the Bariatricus comes , Faecalibacterium prausnitzii , Intestinimonas butyriciproducens , Parvimonas sp001553085 , Gemella morbillorum and Finegoldia magna [208]

Notably, non-oncogenic viruses, including both DNA and RNA viruses such as SARS-CoV-2, murine coronavirus (M-CoV), HSV-1, HHV-7, H1N1, and coxsackievirus B3 (CVB3), primarily enhance their replication within host cells by inducing ferroptosis, facilitating effective host infection