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The BaP metabolite BPDE also interfered with the expression levels of angiogenesis-related factors, such as Notch signaling molecules in HUVECs in vitro (Table 2)

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MariTide (Amgen) is a once-monthly GIP antagonist/GLP-1 agonist showing about 12% to 16% in Phase 2, now in Phase 3

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However, clarity is needed to interpret these findings in the context of depressive vs manic phases