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In vivo models showed that GM changes are sufficient to trigger PD-like pathological, neuroinflammatory and behavioural changes in mice, which can be reversed by restoring a healthy GM [19,20,21]

2.12 GO and KEGG enrichment analysis of differentially expressed genes GO, including biological processes (BP), cellular components (CC), and molecular functions (MF), KEGG enrichment analysis, and visualisation of DEmRNAs were performed using the R-packages clusterProfiler, org.Hs.eg.db, enrichplot, and ggplot2 with p -value thresholds of 0.05)

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