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All animal procedures related to were approved by the Johns Hopkins University Animal Care and Use Committee

The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases

2023;120:e2220300120

The effect of Fer-1 was verified with experimentally administered ventricular Fer-1 in experiments with rats, where it was found to inhibit erastin-induced accumulation of ROS in the cytoplasm and lipids, resulting in a decrease in ROS and lower levels of ferroptosis, demonstrating that Fer-1 could appreciably slow down the onset of ferroptosis in the brain (171)