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163, 164 One study was a randomized double-blind placebo-controlled crossover

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Meta-analysis of expression of hepatic organic anion-transporting polypeptide (OATP) transporters in cellular systems relative to human liver tissue

REDEFINE 1 adults with overweight/obesity, no diabetes GI adverse events were reported in 79.6% of CagriSema participants vs 39.9% on placebo

The lethal dose threshold (LD1) was never achieved in animal safety studies meaning researchers could not identify a dose lethal to 1% of test subjects

Weight Loss Efficacy: Head-to-Head Comparison Primary Phase 3 Results Key Finding: Retatrutide produces 8.3 percentage points more weight loss than CagriSema at 68 weeks