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These nutraceuticals have some mechanisms of action in common, including the inhibition of ACE, the enhancement of NO-mediated vasodilation, interactions with ion channels including the blocking of calcium channels and opening of potassium channels with consequent membrane hyperpolarization, anti-inflammatory effects with reductions in synthesis and release of pro-inflammatory cytokines, and enhancement of endogenous antioxidant actions exerted by different enzymes, such as SOD, GPx, and GSTP

Metabolic acidosis is one of the common complications in CKD patients, mainly caused by impaired ability of the kidneys to excrete an acid load, resulting in acid retention in the body and acidification of the blood (72)

Thyroid 13 , 761764 (2003)

E., Claybourn, M

Caffeine A stimulating antioxidant that helps reduce puffiness and promote a refreshed appearance

10.3390/ijms13022276