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Additionally, melanocortins such as -melanocyte-stimulating hormone (-MSH), produced by both keratinocytes and melanocytes, activate the melanocortin-1 receptor (MC1R) on melanocytes, further enhancing their antioxidant capacity

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At low drug to target ratios, the AMG 966:target complexes exhibited enhanced FcRIa and FcRIIa binding, which diminished as the ratio increased ( Figures 6A, B ), consistent with the immune complex formation observed by SEC-MALS