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Across multiple experimental systems, primarily involving rodent models with implanted breast or liver tumors, the exposure to abnormal lighting conditions (e.g., continuous light, dim LAN, or intermittent light during the dark phase) consistently led to suppressed melatonin production and enhanced tumor growth dynamics 161

Yoshizawa-Fujita, M., Tamura, T., Takeoka, Y

These varying results are likely attributed to interactions between energy and protein intake, as well as the supplementation of essential amino acids and the balance among amino acids

While our study demonstrates that irisin exerts neuroprotective effects on dopaminergic neurons in an MPTP-induced Parkinsons disease mouse model, it is important to consider potential off-target effects associated with systemic administration

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doi: 10.1007/s12602-017-9325-3 114 MiraghajaniM.ZaghianN.MirlohiM.FeiziA.GhiasvandR