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FMT, in particular, faces substantial regulatory scrutiny due to concerns about pathogen transmission and long-term safety[145]

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Comparative analyses of polyamine levels in human normal, benign, and malignant prostatic tissues reveal elevated spermine concentrations in normal and benign hyperplastic prostates, contrasting with reduced spermine levels in tumor tissues, particularly metastatic prostate cancer (65)

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Cytokine release syndrome (CRS) 59 is a life-threatening hyperinflammatory state linked to viral infections, including SARS-CoV-2, and is a frequent adverse effect after chimeric antigen receptor T cell (CAR-T) therapy 59 , where both IL-6 and neutrophil activation are implicated 60,61