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Application of a low-dose microglial inhibitor, minocycline, can dose-dependently enhanced long-term potentiation (LTP) effect of type C nerve fibers in the spinal dorsal horn induced by high-frequency electrical stimulation, whereas high-dose of minocycline reversed this long-term enhancement effect of type C nerve fibers in the spinal dorsal horn induced by high-frequency electrical stimulation to long-term inhibition (129, 130)

Common signs include the above mentioned in the image

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This makes it a practical adjunct for researchers running 12-week or extended protocols who want to protect receptor function without shortening the cycle itself