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This review consolidates recent findings indicating that FOXO4-dependent senescence significantly contributes to neuroinflammation, synaptic dysfunction, and impaired neurogenesis in the aging brain

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10 Focus on natural products in assisted reproductive technology DOR-associated infertility is primarily linked to a reduction in both the number and quality of oocytes, which significantly limits a womans ability to conceive (Steiner et al., 2017)

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Accumulating evidence indicates that AKI is not merely a transient hemodynamic disturbance but a biologically orchestrated process in which dysregulated intracellular signaling pathways translate ischemic stress into sustained renal injury and long-term functional decline

The ratio of reduced GSH to the disulfide form (GSH/GSSG) within the endoplasmic reticulum ranges from 1:1 to 4:1, whereas the overall cellular GSH/GSSG ratio ranges from 30:1 to 100:1 (26) (Figure 2)