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Acta Pharmacol Sin 2000

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Its because we have these tools weve built up at MIT over the years. They also synthesized a shorter sequence of only 12 amino acids found in the alpha helix, and then tested both of the peptides using equipment at MITs Biophysical Instrumentation Facility that can measure how strongly two molecules bind together

5-S-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons

Clinically Important Drug Interactions with PPIs Reduced absorption due to gastric pH Azoles: Ketoconazole, Itraconazole, Posaconazole (oral) Antiretrovirals: Atazanavir , Rilpivirine Oral anticancer drugs (pH-dependent) Erlotinib, Gefitinib, Dasatinib, Nilotinib Iron salts, Calcium carbonate Mycophenolate mofetil Increased exposure / toxicity High-dose Methotrexate delayed clearance & toxicity Warfarin INR (monitor closely) Phenytoin, Diazepam Long-term safety concerns Hypomagnesemia (higher risk with diuretics) Clostridioides difficile infection Fracture risk with prolonged use Clinical Pearl Avoid unnecessary PPIs in patients receiving pH-dependent oral anticancer therapies