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Ciguatoxins: cyclic polyether modulators of voltage-gated iion channel function

DCruz PM, Yasumura D, Weir J, Matthes MT, Abderrahim H, LaVail MM, Vollrath D (2000) Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat

4.5.3.3 Current validation framework status Although numerous studies employ area under receiver operating characteristic curves exceeding 0.8 as diagnostic performance criteria, validation data from independent external cohorts remain insufficient

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The structural organization and functionality of these two players, under physiological conditions and in response to OS, present a tight regulation at multiple levels and involve different partners

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