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Pastore, A., Piemonte, F., Locatelli, M., Lo Russo, A., Gaeta, L

Our bodies were designed to handle stress, detoxify chemicals and preserve cell function, but when the burden increases, those naturally built-in systems can't keep up with demand

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In addition, pre-treatment with the NEDD8-activating enzyme (NAE) inhibitor MLN4924 fully rescued from degradation, highlighting a functional requirement on NEDD8 conjugation, and hence implying the functional involvement of a Cullin-RING ligase (CRL) in the SP3N-induced degradation of FKBP12 35

Cechinel LR, Batabyal RA, Freishtat RJ, Zohn IE