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Based on the patient population we see in Doral, the strongest candidates typically include: Patients with chronic or multi-site injuries: TB-500s systemic distribution makes it particularly relevant for patients with injuries across more than one joint or tissue type, where localized injection alone would require multiple sites per session

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Progressive liver fibrosis also enhances HSC and portal fibroblast activation through matrix rigidity, creating a positive feedback loop of fibrogenesis and oncogenesis (154)

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doi:10.1021/ja0558387 98