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In het werk van Raun et al., 1998 zette ipamorelin groeihormoon dosisafhankelijk vrij, zonder de adrenocorticotrope as meetbaar te activeren

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T-DM1related adverse events (AEs) were mainly of grades 1 or 2, including increased liver transaminases (63%), thrombocytopenia (31%), and nausea (29%)

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Historically, it was believed that maximizing drug doses and prolonging treatment duration could effectively kill tumor cells and prevent the development of drug resistance