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Front Pharmacol (2021) 12:701487

[89] Coadministration of a SOD mimetic along with IONIS SOD1Rx or pyrimethamine may partially address this concern, although to date no such combinational approaches have been investigated

Lack of rest increases cortisol, which can lead to inflammation and skin issues

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The honest position supported by both major 2026 reviews is that the preclinical evidence is mechanistically compelling, no major safety red flags have emerged, and controlled human evidence has been entirely absent