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In particular, NRF2 strongly activates cystine uptake coupled with glutamate excretion and glutathione synthesis, which increases consumption of intracellular glutamate

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This limitation caused by the transformation efficiency may be partially overcome by screening the peptide library repeatedly

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Its expression is dependent on selenium metabolism and the mevalonate pathway, which generates the isopentenyl pyrophosphate required for the maturation of the selenocysteine tRNA essential for the incorporation of Sec into its catalytic site (4547)

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Even the simpler organisms in our world today, such as some bacteria, are actually very complicated in terms of their machinery and genetic coding

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