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Among these agents, sotorasib (AMG 510) and adagrasib (MRTX849) have emerged as promising therapeutic options, demonstrating notable clinical efficacy in patients with KRAS G12C-mutant NSCLC (85,94)

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Alternative analytical approaches include Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF-MS), often coupled with thin layer chromatography (TLC-MALDI) for enhanced separation (Guerrera et al., 2009

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