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The duration of a B12 injections effects varies, but most people experience benefits for a few weeks to a few months

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May-Jun 2006;72(3):350-4

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B12 injections are especially beneficial for: People with pernicious anemia, an autoimmune condition destroying intrinsic factor Those with gastrointestinal disorders affecting absorption Individuals who have undergone gastric surgery or bowel resection Older adults with decreased stomach acid production Patients with severe deficiency requiring rapid replenishment Individuals who struggle with adherence to daily oral supplements Shots offer a reliable, quick way to restore B12 levels in these populations

Crucially, when analysed by sex, 56% of males ( n = 14/25) had IM injections, while the rate was significantly lower in females: only 8% ( n = 2/25)