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However, hypoglycemia, seizures, jaw pain, myalgia, edema, headaches, increased liver and kidney mass, and altered liver function among others (Table 2) have been reported after rhIGF-I administration (Sullivan et al., 1998, Williams, McDonald, OSavage et al., 2008, Laron, 1999, Major, Laughlin, Kritz-Silverstein et al., 2010)