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In many invertebrate models and cell lines, it has been shown that the overexpression of different proteasomal regulatory or catalytic subunits or treatment with specific compounds has positive effects on proteasome activity (Saez and Vilchez, 2014)

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However, no direct lipolytic or anti-inflammatory action has been proven in humans

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Lycopene prevents macrophages from producing proinflammatory cytokines and chemokines, which reduces inflammation in several organs (93, 94)

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