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2025 May 7:157:114764

Two reductases were highly induced in our global transcriptome, lmo0103 and lmo0613 , which we refer to as rha1 and rha2 ( r esistance to h ost a lkenals 1 and 2), respectively

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Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]