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Loss of LKB1, occurring in 1530% of NSCLC cases, leads to profound metabolic reprogramming characterized by increased glycolysis, impaired OXPHOS, altered mitochondrial dynamics, and dysregulated nutrient sensing

Its watersoluble, 95 % purity formulation and short plasma halflife (78 minutes) allow rapid crossing of the bloodbrain barrier, where it enhances deltawave (slowwave) activity the deepest stage of restorative sleep DSIP is a nonapeptide (TrpAlaGlyGlyAspAlaSerGlyGlu) first isolated from rabbit brain and produced in the human hypothalamus

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Since each drug of abuse has a different mechanism of BBB disruption, understanding the effect of polysubstance abuse on BBB could allow the evaluation of novel therapeutic agents and systemic prediction of clinical efficacy

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