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Thyroid hormones must be free of carrier proteins (unbound) to be active (e.g

Some patients have a thymoma, or a tumor in the thymus gland, while others have thymic hyperplasia, or an enlarged gland

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Vascular aging has systemic consequences, affecting multiple organs by promoting oxidative stress, endothelial dysfunction, cellular senescence [44, 68, 69] and apoptosis [70], impaired angiogenesis [62, 71], morphological alterations of endothelial cells [72], and altered vasoregulatory mechanisms [73], ultimately leading to reduced perfusion and metabolic dysregulation [58, 74, 75]